English: Phylogenetic analysis of RNA-dependent RNA polymerases (Pol) of coronaviruses with complete genome sequences available. The tree was constructed by the neighbor-joining method and rooted using Breda virus polyprotein. Bootstrap values were calculated from 1000 trees. 1118 amino acid positions in Pol were included. The scale bar indicates the estimated number of substitutions per 20 amino acids. All abbreviations for the coronaviruses were the same as those in Figure 1.
বণ্টন করতে পারেন – এ কাজটি অনুলিপি, বিতরণ এবং প্রেরণ করতে পারেন
পুনঃমিশ্রণ করতে পারেন – কাজটি অভিযোজন করতে পারেন
নিম্নের শর্তাবলীর ভিত্তিতে:
স্বীকৃতিপ্রদান – আপনাকে অবশ্যই যথাযথ স্বীকৃতি প্রদান করতে হবে, লাইসেন্সের একটি লিঙ্ক সরবরাহ করতে হবে এবং কোনো পরিবর্তন হয়েছে কিনা তা নির্দেশ করতে হবে। আপনি যেকোনো যুক্তিসঙ্গত পদ্ধতিতে এটি করতে পারেন। কিন্তু এমন ভাবে নয়, যাতে প্রকাশ পায় যে লাইসেন্সধারী আপনাকে বা আপনার এই ব্যবহারের জন্য অনুমোদন দিয়েছে।
https://creativecommons.org/licenses/by/3.0CC BY 3.0 Creative Commons Attribution 3.0 truetrue
ক্যাপশন
এই ফাইল কি প্রতিনিধিত্ব করছে তার এক লাইন ব্যাখ্যা যোগ করুন
Coronavirus
कोविड 19
Data pocházejí z porovnání sekvencí virové RNA polymerázy
Uploaded a work by Patrick C. Y. Woo, Yi Huang, Susanna K. P. Lau, and Kwok-Yung Yuen from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185738/ with UploadWizard
এই ফাইলে অতিরিক্ত কিছু তথ্য আছে। সম্ভবত যে ডিজিটাল ক্যামেরা বা স্ক্যানারের মাধ্যমে এটি তৈরি বা ডিজিটায়িত করা হয়েছিল, সেটি কর্তৃক তথ্যগুলি যুক্ত হয়েছে। যদি ফাইলটি তার আদি অবস্থা থেকে পরিবর্তিত হয়ে থাকে, কিছু কিছু বিবরণ পরিবর্তিত ফাইলটির জন্য প্রযোজ্য না-ও হতে পারে।
ছবির শিরোনাম
The drastic increase in the number of coronaviruses discovered and coronavirus genomes being sequenced have given us an unprecedented opportunity to perform genomics and bioinformatics analysis on this family of viruses. Coronaviruses possess the largest genomes (26.4 to 31.7 kb) among all known RNA viruses, with G + C contents varying from 32% to 43%. Variable numbers of small ORFs are present between the various conserved genes (ORF1ab, spike, envelope, membrane and nucleocapsid) and downstream to nucleocapsid gene in different coronavirus lineages. Phylogenetically, three genera, Alphacoronavirus, Betacoronavirus and Gammacoronavirus, with Betacoronavirus consisting of subgroups A, B, C and D, exist. A fourth genus, Deltacoronavirus, which includes bulbul coronavirus HKU11, thrush coronavirus HKU12 and munia coronavirus HKU13, is emerging. Molecular clock analysis using various gene loci revealed that the time of most recent common ancestor of human/civet SARS related coronavirus to be 1999-2002, with estimated substitution rate of 4´10-4 to 2´10-2 substitutions per site per year. Recombination in coronaviruses was most notable between different strains of murine hepatitis virus (MHV), between different strains of infectious bronchitis virus, between MHV and bovine coronavirus, between feline coronavirus (FCoV) type I and canine coronavirus generating FCoV type II, and between the three genotypes of human coronavirus HKU1 (HCoV-HKU1). Codon usage bias in coronaviruses were observed, with HCoV-HKU1 showing the most extreme bias, and cytosine deamination and selection of CpG suppressed clones are the two major independent biological forces that shape such codon usage bias in coronaviruses.
স্রষ্টা
Patrick C. Y. Woo
সংক্ষিপ্ত শিরোনাম
Coronavirus Genomics and Bioinformatics Analysis
জেপিইজি ফাইলের মন্তব্য
The drastic increase in the number of coronaviruses discovered and coronavirus genomes being sequenced have given us an unprecedented opportunity to perform genomics and bioinformatics analysis on this family of viruses. Coronaviruses possess the largest genomes (26.4 to 31.7 kb) among all known RNA viruses, with G + C contents varying from 32% to 43%. Variable numbers of small ORFs are present between the various conserved genes (ORF1ab, spike, envelope, membrane and nucleocapsid) and downstream to nucleocapsid gene in different coronavirus lineages. Phylogenetically, three genera, Alphacoronavirus, Betacoronavirus and Gammacoronavirus, with Betacoronavirus consisting of subgroups A, B, C and D, exist. A fourth genus, Deltacoronavirus, which includes bulbul coronavirus HKU11, thrush coronavirus HKU12 and munia coronavirus HKU13, is emerging. Molecular clock analysis using various gene loci revealed that the time of most recent common ancestor of human/civet SARS related coronavirus to be 1999-2002, with estimated substitution rate of 4´10-4 to 2´10-2 substitutions per site per year. Recombination in coronaviruses was most notable between different strains of murine hepatitis virus (MHV), between different strains of infectious bronchitis virus, between MHV and bovine coronavirus, between feline coronavirus (FCoV) type I and canine coronavirus generating FCoV type II, and between the three genotypes of human coronavirus HKU1 (HCoV-HKU1). Codon usage bias in coronaviruses were observed, with HCoV-HKU1 showing the most extreme bias, and cytosine deamination and selection of CpG suppressed clones are the two major independent biological forces that shape such codon usage bias in coronaviruses.